More Information About Sildenafil

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Sildenafil is used in the treatment of erectile dysfunction and to improve exercise skills in adult patients with pulmonary hypertension.

What is Sildenafil?


Sildenafil works by increasing the flow of blood to the penis following sexual stimulation, thus promoting erection. It is an inhibitor of the enzyme phosphodiesterase, which is therefore also used in the case of pulmonary hypertension, as it relaxes the blood vessels at the pulmonary level.

How is Sildenafil taken?


Sildenafil is administered orally as tablets or as a suspension.

Side effects of Sildenafil


Sildenafil has side effects that occur in the visual or auditory system. Among the former there are sudden drops in vision (up to total loss), while among the latter there are sudden drops or losses of hearing. Heart attack, stroke, irregular heartbeat, brain or lung bleeding, high blood pressure and sudden death are among other side effects of Sildenafil.

Possible side effects of sildenafil include:

  • headache
  • heartburn
  • diarrhea
  • difficulty in distinguishing colors
  • light sensitivity
  • hot flashes
  • epistaxis
  • insomnia
  • burning, numbness or tingling in arms, hands, feet or legs
  • muscle pain

A doctor should be contacted without hesitation in the event that taking the drug gives rise to:

  • difficulty breathing
  • tightness or pain in the chest
  • swelling of the mouth, face, lips or tongue
  • sudden loss of vision, blurred vision
  • sudden reduction or loss of hearing, tinnitus
  • dizziness or feeling light-headed
  • swoon
  • rash
  • urticaria
  • itch
  • worsening of respiratory distress
  • painful erections or lasting more than four hours
  • burning or itching during urination


Contraindications and warnings on the use of Sildenafil


If you have recently taken Riociguat or nitrates, or if their intake continues, taking Sildenafil is contraindicated. In addition, it is advisable to inquire about the risks that grapefruit or grapefruit juice may cause during treatment with sildenafil.

It is advisable to notify your doctor before starting sildenafil therapy:

allergies to the active substance, its excipients, any other medicines, foods or other substances;
medicinal products, herbal remedies and supplements can be taken, in particular, alpha – blockers, amlodipine, anti-fungal, blood thinners, barbiturates, beta-blockers, Bosentan, Cimetidine, Efavirenz, Erythromycin, HIV protease inhibitors, Nevirapine, medicines against high blood pressure, anticonvulsants, Rifabutin, Rifampicin, st. john’s Wort and other medicines against erectile dysfunction;

  • if in the past you have suffered, or still suffer from prolonged erections, veno-occlusive disease pulmonary, gastric ulcers, heart disease, liver or kidney disease, bleeding disorders, circulation problems, disorders involving the cells of the blood, conditions that alter the shape of the penis, diabetes, retinitis pigmentosa or sudden loss of vision (especially if it is associated to block the flow of blood to the nerves of sight), angina during sexual intercourse;

  • in case of heart attack;
  • in the presence of family cases of retinitis pigmentosa or sudden loss of vision (especially if associated with blockage of blood flow to the nerves of vision);
  • if you are smoking;
  • if you have experienced dehydration (even recent);
  • if you have ever been prescribed to reduce sexual activity (even in the past);
  • if you are a woman suffering from pulmonary hypertension, in case of pregnancy or lactation.

Your doctor, surgeon or dentist should be informed of Sildenafil intake.

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Do not begin, cease, or change the dosage of any medicines without your physician’s approval. To treat erectile dysfunction-ED, take this drug by mouth as directed by your physician, normally as needed. Take sildenafil at least half-hour, however no more than four hours, before sexual activity . Viagra® was FDA-approved in 1998 and has been […]

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